Course curriculum

  • 1

    Course Outline

    • Introduction to the Course

    • Acknowledgements

    • First Semester Diversity and Inclusion Module also Available!

    • Disclaimer

  • 2

    Aromatic Compounds

    • Aromaticity

    • Basicity of Nitrogen in Aromatic Molecules

    • Nomenclature of Aromatic Compounds

    • Friedel-Crafts Alkylation: An Intramolecular Example

    • Substituent Effects on Electrophilic Aromatic Substitution

    • Directing Effects in Electrophilic Aromatic Substitution

    • Radical Halogenation of Allylic Sites

    • Diazotization and Azo Coupling

  • 3

    Organometallic Chemistry

    • Carbenes: Beyond Cyclopropanation

    • Grignard Reagents: Reactions with Ketones and Ketenes

    • Hydride Reagents

    • Palladium-Catalyzed Coupling Reactions

    • Alkene (Olefin) Metathesis

  • 4

    Carbonyl Compounds

    • Variable Reactivity of Carbonyl Functional Groups

    • Reaction of Carbon-Centered Nucleophiles with Ketones and Aldehydes

    • Acetal Formation and Hydrolysis

    • Preparation and Reaction of Imines

    • Formation of Alkenes from Carbonyls: Wittig-Like Reactions

    • Nucleophilic Acyl Substitution

    • Ester Hydrolysis and Saponification

    • Amide/Lactam Hydrolysis: Influence of Steric Strain

    • Reactivity of Nitriles and the Origin of Biomolecules

    • Enolates as Nucleophiles

    • Gabriel Malonic Ester Synthesis and Isotopic Labeling

    • Addition of Nucleophiles to alpha,beta-Unsaturated Carbonyls